Peptides / MK-677
MK-677
(Ibutamoren)T2General Wellnessliterature
Biomarker Effects
IGF-1
↑ large
Ghrelin receptor agonist
Fasting glucose
↑ small
Transient insulin resistance
Growth hormone
↑ large
Stimulates pituitary GH release
IGFBP-3
↑ moderate
GH-mediated binding proteins
Cortisol (AM)
↓ small
Improves sleep architecture
Sleep efficiency
↑ moderate
Improves sleep quality
Melatonin (endogenous)
↓ small
Circadian regulation
Appetite
↑ moderate
Ghrelin agonism
Water retention
↑ small
GH-related fluid retention
HbA1c
↑ small
May worsen glycemic control
Fasting insulin
↑ small
Insulin resistance
Edema
↑ small
GH-related fluid retention
Ghrelin
↑ large
Ghrelin receptor agonism
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